in the treatment of metastatic cancer of the colon and rectum,

as adjunctive therapy for colon and rectal cancer,

in the treatment of advanced stomach cancer,

in the treatment of advanced pancreatic cancer,

in the treatment of advanced esophageal cancer,

in the treatment of advanced or metastatic breast cancer,

as adjunctive therapy in patients with operable primary invasive breast cancer,

in the treatment of non-operable locally advanced squamous cell carcinoma of the head and neck in patients who have not received prior treatment,

in the treatment of locally recurrent or metastatic squamous cell carcinoma of the head and neck.